The United States is a melting pot of diverse ethnic groups, each with unique cultural backgrounds, health practices, and anatomical differences. For healthcare providers, understanding these differences is crucial in delivering culturally competent and effective care. This section introduces six major ethnic groups in America—White, Black, Hispanic/Latino, East Asian, Indian, and Native American/Pacific Islander—highlighting key anatomical distinctions and cultural practices. By adjusting their care strategies to accommodate these differences, healthcare professionals can enhance patient satisfaction, improve health outcomes, and reduce health disparities.